The Ruins of Illusk - NWN Side Quest (Chapter 2)
The Ruins of Illusk is a side quest that takes place in Luskan, a town you'll be spending time in at the end of Chapter 2. Unlike the other quests here this one doesn't begin by talking to an NPC. Instead, you'll have to defeat a Skull Warrior enemy inside of an Abandoned House in the Luskan - Docks (pictured above) and loot his head to put on a nearby Altar.
If you're having trouble finding this Abandoned House open your map while you're in the Luskan - Docks zone and check the map markers in the southwest. There will be 2 of them next to each other and one of them will be marked 'Abandoned House'. When you actually enter this building though it'll be called Ruined House, because it just has to be confusing.
As aforementioned once you take out the Skull Warrior you'll want to pick up Skull Warrior's Head and place it into the glowing red Altar nearby. This will begin the quest and also open the nearby door that leads downstairs into the Ruins of Illusk. For this quest you'll be tasked with clearing out all 3 levels of the Ruins and defeating the big baddie at the end.
How this dungeon works is in order to progress to floors 2 and 3 you'll need to obtain an item from a named that is near the stairs that go down. Then, much like at the start of this dungeon, you'll have to put the item into the nearby Altar to open the door forward.
The first named you'll be fighting is the Fallen Hero (pictured above), you'll need to defeat him and loot the Hero's Heart item. Place that into the Altar and you'll open the door to Level 2. On Level 2 you're going to be fighting Water Elemental Guardian who is extremely annoying since he can one shot you with Drown. It's a Fortitude save, though my best advice to protect against it is send a Henchman in to meet their doom.
Water Elemental Guardian drops Blessed Water which you'll put inside the Altar to open the next door. On the 3rd level you'll find Voleron in the south-central area. Defeating him will complete the quest, make sure you loot everything on your way out as there is a lot here.