A Telkine in Egypt - Act 2 Story Quest
A Telkine in Egypt is the third main quest of Act 2 in Titan Quest and if you haven't already gotten Diablo 2 vibes from this whole quest line you will now. You need to go to the Valley of the Kings and search for the Tomb of Ramses to kill Duriel, I mean, a Telkine. Thankfully in Titan Quest you do not have to search for the right tomb, you can always find the Tomb of Ramses in the same place - northwest of the Portal.
Leave Memphis out of the gate near Imhotep and travel northwest until you find the Thebes aka Temple of Seti, it's not too far of a run. Grab the Portal in Thebes and then go northeast to the Valley of Kings where there will be another Portal.
Once you are in the Valley of Kings travel northwest until you find the Tomb of Ramses. You can mouse over the tombs on your mini map until you find the right one. The Telkine that we're after can be found all the way at the bottom (obviously). It's a far run.
Aktaios is a pretty easy fight so long as you avoid his worst attacks. The pillar behind me in the screenshot above is my favorite one to stand behind during this fight. If you are Melee you'll need to come out from behind the pillar to damage Aktaios but ranged can hide behind it the whole time.
Most of Aktaios' attacks will hit this pillar rather than you if you stand behind it and Aktaios will almost never come up to you because he likes to stay in the middle of the arena where his Light of Ra attack can hit you.
Fireballs: He lobs Fireballs at you that also create an AoE on the ground where they land, kinda like Volcanic Orb in Earth Mastery
Light of Ra: Rays of Sunlight burst through the ceiling and deal high Fire Damage to anything it hits. These always come down in the same locations so they are easy to dodge.
Mirror Image: He creates duplicates of himself that can do basic attacks. They are much weaker than he is and you can usually easily tell them apart by how fast their health bar drops. Or a DoT which you had on the boss prior to him duplicating.
Summon Guardians: Two undead dogs are created which will assist him.
Sandstorm: An AoE attack which he does around himself when you melee him. It disrupts your skills and deals heavy damage
With Aktaios defeated you will want to pick up the Cuneiform Tablet and return it to Imhotep who is at the Temple of Seti in Thebes. Doing so will complete this quest and begin the next and final quest of Act 2, The Sickle of Kronos.