Enigma: Armor Rune Word - Diablo 2
Enigma is the most popular best in slot Rune Word in the entire game because it is one of the only items that offers the Teleport ability. Necromancers, Paladins, Druids, basically every character except Sorceress' and Amazons will have a build or two that Enigma is the recommended best in slot item for. Some of the builds for these classes are based entirely around Enigma and won't function without it.
Sorceress' come with Teleport built into their class and Amazons have too slow of frames when casting to make Teleport as useful for them.
Keep in mind that all Rune Words you create will retain any pre-existing bonuses found on the item. If you find a 'Superior' piece of armor with +Enhanced Defense, a Superior Weapon with +Enhanced Damage or a Helm/Weapon that has +Skill bonuses for a certain class, all of these will remain on the final Rune Word that is created. It's also possible to 'ebug' a piece of Ethereal Armor that you find which will increase the Defense bonuses by 50%, check out my Ebugging Guide for more information.
Farming High Runes: Out of all locations in the game one stands above the rest for farming specifically High Runes, the Countess during Act 1. The Countess has a guaranteed chance to always drop a High Rune and can even drop more than one. Check out my The Countess Farming Guide for more information.
Required Runes:
Level Req: 65
Other Req: N/A
Slots: Chest Armor
+2 To All Skills
+45% Faster Run/Walk
+1 To Teleport
+750-775 Defense (Varies)
+(0.75*Clvl) To Strength (Based On Character Level)
Increase Maximum Life 5%
Damage Reduced By 8%
+14 Life After Each Kill
15% Damage Taken Goes To Mana
(1*Clvl)% Better Chance of Getting Magic Items (Based On Character Level)
Enigma Rune Word in Sacred Armor.
Enigma in Superior Wyrmhide.